中国组织工程研究 ›› 2011, Vol. 15 ›› Issue (39): 7388-7391.doi: 10.3969/j.issn.1673-8225.2011.39.042

• 骨与关节学术探讨 academic discussion of the bone and joint • 上一篇    下一篇

髋假体置入后假体周围松动骨质的病理学变化

王燕嬉1,孟祥英2   

  1. 1白城医学高等专科学校基础医学部病理教研室,吉林省白城市 137000
    2解放军第251医院,河北省张家口市 075000
  • 收稿日期:2011-06-18 修回日期:2011-08-11 出版日期:2011-09-24
  • 作者简介:王燕嬉★,女,1974年生,吉林省镇赉县人,汉族, 2007年吉林大学毕业,硕士,中级讲师,主要从事病理与病理生理学研究。 shenymengf@126.com

Pathological changes of loosening bone around the implanted hip prosthesis

Wan Yan-xi1, Meng Xiang-ying2   

  1. 1Department of Pathology, Basic Medicine School, Baicheng Medical College, Baicheng  137000, Jilin Province, China
    2the 251 Hospital of Chinese PLA, Zhangjiakou  075000, Hebei Province, China
  • Received:2011-06-18 Revised:2011-08-11 Online:2011-09-24
  • About author:Wang Yan-xi★, Master, Lecturer, Department of Pathology, Basic Medicine School, Baicheng Medical College, Baicheng 137000, Jilin Province, China shenymengf@126.com

摘要:

背景:磨损颗粒是导致假体周围骨质溶解的重要潜在性因素之一,但引起假体周围骨溶解的原因及其发展过程尚未完全清楚。
目的:复习人工关节置换后翻修病例的病理切片,分析病理检查在人工关节置换后感染诊断中的价值。
方法:由第一作者检索1990/2008 PubMed数据及万方数据库有关髋假体置入后假体周围松动以及假体松动周围骨质的病理学变化方面的文献。
结果与结论:人工假体与骨空隙的产生导致界膜充填,磨损微粒刺激界膜释放炎性细胞因子导致骨溶解而出现假体松动,如果尽可能地减少活动中产生的磨损碎屑可减少炎性递质的释放;减少由充填性界膜向溶骨性界膜的转变,就可从生物学角度降低人工髋关节置换后假体松动的发生率。

关键词: 人工关节, 磨损颗粒, 界面, 骨形成, 体内研究

Abstract:

BACKGROUND: Wear particles are the important potential factor leading to periprosthetic osteolysis, but the cause of periprosthetic osteolysis and its development process are still unclear.
OBJECTIVE: To analyze the vale of pathological examination in the diagnosis of infection after total joint arthroplasty based on review of pathological sections after total joint arthroplasty.
METHODS: The first author searched PubMed and CNKI databases (1990/2008) for articles about loosening bone around the implanted hip prosthesis and relevant pathological changes.
RESULTS AND CONCLUSION: The gap between the prosthesis and bone is filled with the interface membrane, and wear particles induce the interface membrane to release inflammatory cytokines leading to loosening prosthesis. To minimize wear debris generation can reduce the release of inflammatory neurotransmitters. The incidence of loosening prosthesis after total joint arthroplasty can be reduced by decreasing the osteolytic changes of the interface membrane.

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