中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (4): 638-641.doi: 10.3969/j.issn.1673-8225.2012.04.016

• 人工假体 artificial prosthesis • 上一篇    下一篇

人工腰椎间盘置换治疗退行性腰椎间盘疾病16例分析*☆○

吴  亮1,孙晓亮1,张  雷1,吴国峰1,周  剑1,Yve Cartonne2○,Pascal Moussellard2○   

  1. 1苏州大学常州第一人民医院骨1科,江苏省常州市 213003;2Pitie- Salpetriere Hospital,the 6th University of Paris,France
     
  • 收稿日期:2011-07-25 修回日期:2011-11-12 出版日期:2012-01-22
  • 作者简介:吴亮☆,男,1975年生,江苏省常州市人,2005年南京大学医学院毕业,博士,副主任医师,硕士生导师,主要从事脊柱外科方面的研究。drwuliang@tom.com
  • 基金资助:

    常州市卫生局青年人才项目(QN200805)。

Preliminary clinical results of artificial disc replacement for degenerative disc disease in 16 cases

Wu Liang1, Sun Xiao-liang1, Zhang Lei1, Wu Guo-feng1, Zhou Jian1, Yve Cartonne2○, Pascal Moussellard2○   

  1. 1Department of Orthopedics, the First People’s Hospital of Changzhou, Soochow University, Changzhou  213003, Jiangsu Province, China; 2Pitie-Salpetriere Hospital, the 6th University of Paris, France
  • Received:2011-07-25 Revised:2011-11-12 Online:2012-01-22
  • About author:Wu Liang☆, Doctor, Associate chief physician, Master’s supervisor, Department of Orthopedics, the First People’s Hospital of Changzhou, Soochow University, Changzhou 213003, Jiangsu Province, China drwuliang@tom.com
  • Supported by:

    the Special Foundation for Young Scientists of Changzhou Municipal Health Bureau, No. QN200805*

摘要:

背景:与传统的单纯腰椎间盘切除和脊柱融合治疗方法相比,人工腰椎间盘置换具有明显的理论优势,已成为治疗退行性腰椎间盘疾病的最有希望的方法。
目的:总结人工腰椎间盘置换治疗退行性腰椎间盘疾病的初步临床疗效。
方法:2007-05/2010-10行人工腰椎间盘置换治疗退行性腰椎间盘疾病16例,其中男9例,女7例,平均年龄40.5岁(28~55岁)。
结果与结论:随访时间6~36个月,置换后目测类比评分、Oswestry功能障碍指数、椎间隙高度均较置换前有显著改善(P < 0.01)。置换后腰椎活动度获有效维持,置换后腰椎活动度与置换前比较差异无显著性意义(P > 0.05)。结果显示人工腰椎间盘置换治疗退行性腰椎间盘疾病的初步临床结果令人满意,但其远期效果尚待进一步观察。

关键词: 腰椎, 椎间盘, 假体, 植入物, 退行性腰椎间盘疾病

Abstract:

BACKGROUND: Simple discectomy and spinal fusion surgery were the classical methods for the degenerative disc disease. Comparing to them, artificial disc replacement (ADR) showed more theoretical superiority.
OBJECTIVE: To present the preliminary clinical results of ADR for the treatment of degenerative disc disease.
METHODS: From May 2007 to October 2010, ADR were preformed on 16 cases for the treatment of degenerative disc disease. 9 males and 7 females with average age of 40.5 years underwent ADR.
RESULTS AND CONCLUSION: The follow-up time averaged 21.5 months (6-36 months). Postoperative visual analogue scale, Oswestry Disability Index and intervertebral height were significantly improved as compared with those in preoperation (P < 0.01). The postoperative range of motion (ROM) of the involved lumbar segment was effectively kept. The ROM before and after operation showed no significant difference (P > 0.05). ADR can acquire satisfactory preliminary clinical results for the treatment of degenerative disc disease. However, further research is needed to study its long-term impact.

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