中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (11): 2039-2042.doi: 10.3969/j.issn.1673-8225.2012.11.032

• 组织构建学术探讨 tissue construction academic discussion • 上一篇    下一篇

骨形态形成蛋白在下颌骨快速牵张成骨中的应用*★

刘  浩,王  敏   

  1. 四川大学华西口腔医院修复科,四川省成都市  610041
  • 收稿日期:2011-09-17 修回日期:2011-09-27 出版日期:2012-03-11
  • 通讯作者: 王敏,博士,教授,四川大学华西口腔医院修复科,四川省成都市 610041 hxkqwangm@163.com
  • 作者简介:刘浩★,男,1986年生,重庆市人,汉族,四川大学在读硕士,主要从事口腔修复学研究。liuhaofrank@163.com
  • 基金资助:

    四川省科技厅公益项目(2008FN0174),原发性高血压与牙槽骨吸收相关性研究。

Application of bone morphogenetic proteins in mandibular fast distraction osteogenesis

Liu Hao, Wang Min   

  1. Department of Prosthodontics, West China College of Stomatology, Sichuan University, Chengdu  610041, Sichuan Province, China
  • Received:2011-09-17 Revised:2011-09-27 Online:2012-03-11
  • Contact: author: Wang Min, Doctor, Professor, Department of Prosthodontics, West China College of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China hxkqwangm@163.com
  • About author:Liu Hao★, Studying for master’s degree, Department of Prosthodontics, West China College of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China liuhaofrank@163.com
  • Supported by:

    Public Project of Science and Technology Agency of Sichuan Province, No. 2008FN0174*

摘要:

背景:牵张成骨已经成为治疗不同类型颅面畸形和骨缺损的有效的方法,但是牵张成骨的主要缺点是牵张期和稳定期比较长,可能导致牵张过程中严重的并发症。
目的:总结骨形态形成蛋白在快速牵张成骨过程中作用的研究现状。
方法:电子检索计算机Pubmed数据库(1989/2011)收录的骨形态形成蛋白和牵张成骨相关综述和论文报告。
结果与结论:共纳入骨形态形成蛋白在快速牵张成骨中的作用相关文献32篇。骨形态形成蛋白具有很强的成骨活性,能促进骨再生和骨改建。目前的研究显示应用骨形态形成蛋白能加快牵张成骨过程中新骨形成和缩短治疗的疗程。但是骨形态形成蛋白应用于临床还需要进一步的研究。

关键词: 骨形态形成蛋白, 牵张成骨, 骨再生, 下颌骨, 基因治疗

Abstract:

BACKGROUND: Distraction osteogenesis has became an effective method in treatment of different kinds of craniofacial deformities and bone defects. However, the major disadvantage of this method is the long distraction and consolidation period, which may lead to severe complications during the distraction process.
OBJECTIVE: To summarize the research progress of the application of bone morphogenetic proteins (BMPs) in fast distraction osteogenesis.
METHODS: A computer-based online search in Pubmed database was performed to select the reviews and papers related to BMPs and distraction osteogenesis from 1989 to 2011.
RESULTS AND CONCLUSION: A total of 32 literatures on the the application of BMPs in fast distraction osteogenesis were included. BMPs have a strong osteogenic activity and capability of promoting regeneration and remodeling of bone. The present research shows that BMPs can be used to accelerate new bone formation and shorten the treatment period. However, the clinical application of BMPs needs further research.

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