中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (11): 2047-2050.doi: 10.3969/j.issn.1673-8225.2012.11.034

• 组织构建基础实验 basic experiments in tissue construction • 上一篇    下一篇

应力刺激与骨保护蛋白、核因子κB受体活化因子及其配体骨代谢信号通路**★

王  丹,鲍  捷,王国祥   

  1. 苏州大学体育学院,江苏省苏州市 215021
  • 收稿日期:2011-09-07 修回日期:2011-12-14 出版日期:2012-03-11
  • 通讯作者: 王国祥,博士,教授,博士生导师。kwang63@163.com
  • 作者简介:王丹★,女,1988年生,河北省保定市人,苏州大学体育学院在读硕士。wangdan6953@126.com
  • 基金资助:

    课题由江苏省2011年度普通高校研究生科研创新计划项目(CXZZ11_0069)和2011江苏省省属高校自然科学研究面上项(11KJD320001)资助。

Stress stimulation and signal pathways of osteoprotegerin, receptor activator of nuclear factor kappa B and its ligand in bone metabolism 

Wang Dan, Bao Jie, Wang Guo-xiang   

  1. Department of Physical Education, Soochow University, Suzhou  215021, Jiangsu Province, China
  • Received:2011-09-07 Revised:2011-12-14 Online:2012-03-11
  • Contact: author: Wang Guo-xiang, Doctor, Professor, Doctoral supervisor, Department of Physical Education, Soochow University, Suzhou 215021, Jiangsu Province, China kwang63@163.com
  • About author:Wang Dan★, Studying for master’s degree, Department of Physical Education, Soochow University, Suzhou 215021, Jiangsu Province, China wangdan6953@126.com
  • Supported by:

    the Jiangsu Provincial Innovative Research Program for Postgraduates in Regular Institutions of Higher Learning in 2011, No. CXZZ11_0069*; the Key Program of Natural Science Foundation of Jiangsu Province for Provincial Colleges and Universities, No. 11KJD320001*

摘要:

背景:骨保护蛋白、核因子κB受体活化因子及其配体(osteoprote-gerin/ ligand of receptor activator of NF-κB/receptor activator of NF-κB,OPG/RANKL/RANK)骨代谢信号通路是对应力敏感的通路之一。不同性质的运动会产生不同的机械应力刺激,影响骨代谢信号通路。
目的:观察不同性质的运动对OPG/RANKL/RANK信号通路的影响。
方法:由第一作者于2000/2011通过计算机检索 CNKI,HighWire和Elsevier数据库中关于“应力刺激与OPG/RANKL/RANK”的相关的论文报告。以“应力刺激,OPG/RANKL/RANK”或“应力刺激,骨代谢”为检索词进行检索。选择的文章内容与应力刺激对信号通路的影响有关,选择相关近期发表的文献或者是发表在权威期刊的文献。共检索到215篇文章,按纳入和排除标准对文献进行筛选,共纳入31篇文章。
结果与结论:运动对骨骼不断产生机械应力刺激,这种机械应力刺激可以通过影响成骨细胞和破骨细胞的OPG/RNAKL/RANK信号调节系统而调节骨组织代谢。但是相关文献中的研究结果不一致,有待进一步的研究。

 

关键词: 应力刺激, OPG/RANKL/RANK, 信号通路, 成骨细胞, 破骨细胞, 组织工程

Abstract:

 

BACKGROUND: Signal pathway of osteoprotegerin, receptor activator of nuclear factor kappa B and its ligand in bone metabolism is one of the accesses to cope with the stress sensitivity. Different types of the exercise can produce different types of stress stimulation, and influence the signal pathways in bone metabolism.
OBJECTIVE: To explore the influence of different types of exercise on the signal pathways of osteoprotegerin, receptor activator of nuclear factor kappa B and its ligand in bone metabolism.
METHODS: An online search of CNKI, HighWire and Elsevier databases was performed for articles related to “stress stimulation, osteoprotegerin, receptor activator of nuclear factor kappa B and its ligand”. Articles published from 2000 to 2011 with the keywords of “stress stimulation, osteoprotegerin, receptor activator of nuclear factor kappa B and its ligand” or “stress stimulation, bone metabolism” were included. Articles related to the effects of stress stimulation on the signaling pathways were selected. Articles published recently or in the authorized journals were of priority. A total of 215 articles were collected in the initial research, and 31 of them were retained according to inclusion and exclusion criteria.
RESULTS AND CONCLUSION: Exercise continuously produces stress stimulation on bone. This mechanical stress stimulation regulates the bone tissue metabolism by affecting the signal regulating system of osteoprotegerin, receptor activator of nuclear factor kappa B and its ligand. But the results in relevant articles are inconsistent. Therefore further study is needed.
 

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