中国组织工程研究 ›› 2017, Vol. 21 ›› Issue (20): 3275-3280.doi: 10.3969/j.issn.2095-4344.2017.20.025

• 组织构建临床实践 clinical practice in tissue construction • 上一篇    

肾移植术后新发糖尿病:危险因素的回顾性分析

杨  进1,方  芳2,杨  富2   

  1. 1上海交通大学护理学院,上海市  200080;2上海市第一人民医院,上海市  200080
  • 修回日期:2017-03-29 出版日期:2017-07-18 发布日期:2017-07-18
  • 通讯作者: 方芳,硕士,主任护师,上海市第一人民医院,上海市 200080
  • 作者简介:杨进,女,1988年生,河南省卢氏县人,汉族,上海交通大学在读硕士,主要从事危重症肾移植方向研究。

Risk factors for new-onset diabetes mellitus after kidney transplantation: a retrospective study

Yang Jin1, Fang Fang2, Yang Fu2   

  1. 1School of Nursing, Shanghai Jiao Tong University, Shanghai 200080, China; 2Shanghai General Hospital, Shanghai 200080, China
  • Revised:2017-03-29 Online:2017-07-18 Published:2017-07-18
  • Contact: Fang Fang, Master, Chief nurse, Shanghai General Hospital, Shanghai 200080, China
  • About author:Yang Jin, Studying for master’s degree, School of Nursing, Shanghai Jiao Tong University, Shanghai 200080, China

摘要:

文章快速阅读:

文题释义:
移植术后新发糖尿病:
是肾移植后一种常见的代谢并发症,于1964年由Starlz等在肾移植术后的患者中首先发现。肾移植术后新发糖尿病的发病机制尚未明确,可能与胰岛素抵抗和胰岛素分泌不足有关。移植术后新发糖尿病可以直接或者间接地导致不良的临床结果,对移植肾和患者均产生长期不良影响,增加感染性疾病和心血管并发症的发生率,降低人/肾存活率,近年来已经被认为成为仅次于急慢性排斥反应的第二大影响长期生存的因素。
肾移植:是将健康者的肾脏移植给有肾脏病变并丧失肾脏功能的患者,是治疗慢性肾功能衰竭的一项有效手段。肾移植因其供肾来源不同分为自体肾移植、同种肾移植和异种肾移植,习惯把同种肾移植简称为肾移植。其他两种肾移置则冠以“自体”或“异种”肾移植以资区别。

 

摘要
背景:
肾移植后代谢紊乱对预后的影响,尤其是新发糖尿病开始引起学者的重视。
目的:了解肾移植术后新发糖尿病的危险因素,为识别肾移植术后新发糖尿病的高危患者,以及采取相应的预防措施提供参考依据。
方法:回顾性病例分析365例同种异体肾移植患者的临床资料,根据是否发生肾移植术后新发糖尿病,将患者分为肾移植术后新发糖尿病组(71例)和非肾移植术后新发糖尿病组(294例),采用单因素分析和非条件Logistic回归分析肾移植术后新发糖尿病的独立危险因素。
结果与结论:①1年内肾移植术后新发糖尿病的累积发病率为19.45%;②非条件Logistic回归中分析结果显示,年龄≥45岁、体质量指数≥25 kg/m2、糖尿病家族史、急性排斥反应是肾移植术后新发糖尿病发生的独立危险因素;③结果提示,移植时年龄、糖尿病家族史、移植前体质量指数较高及移植后急性排斥反应的发生将会增加肾移植术后新发糖尿病的风险。

 

ORCID: 0000-0002-3578-1252(杨进)

关键词: 组织构建, 组织工程, 肾移植, 新发糖尿病, 危险因素

Abstract:

BACKGROUND: Effect of metabolic disorders after kidney transplantation on prognosis, especially new-onset diabetes after transplantation (NODAT), has aroused concerns.
OBJECTIVE: To investigate the risk factors for NODAT in renal transplant recipients, thus providing reference for identifying high-risk patients and taking active prevention measures.
METHODS: Clinical data of 365 patients undergoing allograft renal transplantation were analyzed retrospectively. According to whether NODAT occurred or not, all the patients were assigned to NODAT (n=71) and non-NODAT (n=294) groups. The independent risk factors for NODAT were determined using univariate 
and non-conditional multivariate logistic regression analysis.
RESULTS AND CONCLUSION: The cumulative incidence of NODAT in renal transplant recipients within year postoperatively was 19.45%. Non-conditional multivariate logistic regression analysis showed that age ≥ 45 years old, body mass index ≥ 25 kg/m2, family history of diabetes mellitus and acute rejection were associated with NODAT in renal transplant recipients. To conclude, the age, family history of diabetes mellitus, high body mass index and acute rejection can increase the incidence of NODAT in renal transplant recipients.

 

Key words: Kidney Transplantation, Diabetes Mellitus, Risk Factors, Tissue Engineering

中图分类号: