中国组织工程研究 ›› 2016, Vol. 20 ›› Issue (43): 6514-6520.doi: 10.3969/j.issn.2095-4344.2016.43.019

• 生物材料综述 biomaterial review • 上一篇    下一篇

口腔科氢氧化钙制剂的临床应用评价

聂二民1,姜  瑞1,张春元1,曾尽娣2,谈济州1,黄喆逊1
  

  1. 1中山大学附属第一医院口腔科,广东省广州市  510080;2广州医科大学第一医院口腔科,广东省广州市  510120
  • 收稿日期:2016-08-12 出版日期:2016-10-21 发布日期:2016-10-21
  • 通讯作者: 张春元,教授,中山大学附属第一医院口腔科,广东省广州市 510080 
  • 作者简介:聂二民,男,1980年生,河南省许昌市人,汉族,2007年中山大学毕业,硕士,主治医师,主要从事口腔临床医学方面研究。
  • 基金资助:

    广东省科技厅社会发展项目(2011B080701086、2011B080701010、2012B061700066)

Application of calcium hydroxide preparation in the dental field

Nie Er-min1, Jiang Rui1, Zhang Chun-yuan1, Zeng Jin-di2, Tan Ji-zhou1, Huang Zhe-xun1
  

  1. 1Department of Stomatology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China; 2Department of Stomatology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, Guangdong Province, China
  • Received:2016-08-12 Online:2016-10-21 Published:2016-10-21
  • Contact: Zhang Chun-yuan, Professor, Department of Stomatology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China
  • About author:Nie Er-min, Master, Attending physician, Department of Stomatology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China
  • Supported by:
    the Social Development Project of Science and Technology Department of Guangdong Province, No. 2011B 080701086, 2011B080701010, 2012B061700066

摘要:

文章快速阅读:

 

文题释义:
氢氧化钙
:又名生石灰、灰钙粉[Ca(OH)2],是建筑业不可缺少的材料,在常温条件下为白色粉末状固体,微溶于水,它的水溶液成为石灰水,对衣服、皮肤具有腐蚀作用,具有强碱性,pH值在10-12之间,化学性质稳定,以往作为一种工业应用的化学物质,主要被应用于建筑、化工、食品等领域,在医学方面,因其良好的可塑性、具有一定的强度、去除方便等优点,被作为骨折外固定的首选,在骨科应用较广泛。
用于临时修复体黏结的氢氧化钙制剂:①材料无毒、无刺激,对牙髓、牙周组织无伤害。②性能稳定,溶解度低;③不释放有害物质,不诱发不良反应;④具有良好的黏结强度,有一定的抗压强度和抗张强度;⑤具有一定的流动性,不妨碍临时冠就位;⑥颜色稳定;⑦凝固时间短;⑧最终修复戴入前,能够彻底清除;⑨对永久性黏结不会造成影响等。

背景:氢氧化钙在临床口腔科应用较为广泛,随着材料科学的发展,其临床应用、物理学性能及生物安全性也越来越优越。
目的:总结氢氧化钙材料的物理性能、生物安全性及临床应用现状。
方法:以“Calciumhydroxide, Calciumhydroxidepreparation”为英文检索词,以“氢氧化钙, 氢氧化钙制剂”为中文检索词,应用计算机检索PubMed数据库和中国知识网数据库中2010年1月到2016年1月发表的相关文章。
结果与结论:氢氧化钙制剂,根据组成分可为单组分和双组分,根据固化形式可分化学固化和光固化,根据性状不同可分为粉剂型和糊剂型。氢氧化钙制剂具有良好的理化性质,可用于口腔根管封药、根管充填、直接盖髓、间接盖髓、活髓切断术及根尖诱导等,临床评价和实验研究认为氢氧化钙制剂具有较好的生物安全性且临床应用效果较好,但在其实验室研究和临床应用的探索过程中,还有许多亟待解决和深入探究的问题。 
ORCID: 0000-0001-9426-1604(张春元)

关键词: 生物材料, 口腔生物材料, 氢氧化钙, 氢氧化钙制剂, 临床应用, 物理性能, 生物安全性

Abstract:

BACKGROUND: Calcium hydroxide has been used widely in clinical dental field, and its physical properties and bio-safety become more excellent along with the development of material science.
OBJECTIVE: To summarize the physical properties, bio-safety and clinical application of calcium hydroxide materials.
METHODS: A computer-based online research was performed in PubMed and CNKI databases using the keywords of “calcium hydroxide, calcium hydroxide preparation” in English and in Chinese, respectively, to retrieve relevant articles published from January 2010 to January 2016.
RESULTS AND CONCLUSION: Calcium hydroxide preparation can be respectively divided into mono-component and bio-component, chemical curing and light curing, as well as power form and paste form according to its components, curing form and characteristics. Calcium hydroxide preparation has good physicochemical properties that can be used for dental root canal, root canal filling, direct pulp capping, indirect pulp capping, vital pulpotomy, and apexification. Clinical evaluation and experimental research have confirmed that the calcium hydroxide preparation has good biological safety and clinical effects; however, some urgent problems still need to be studied in depth. 

Key words: Dental Pulp Capping, Apexification, Review, Tissue Enginnering

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