中国组织工程研究 ›› 2018, Vol. 22 ›› Issue (18): 2933-2938.doi: 10.3969/j.issn.2095-4344.0855

• 生物材料综述 biomaterial review • 上一篇    下一篇

唑来膦酸在骨质疏松状态下影响口腔种植体骨的结合

黄晓林,姚 超,程余婷,李 芳,王 永,廖 健   

  1. 贵州医科大学口腔医学院/附属口腔医院,贵州省贵阳市 550004
  • 收稿日期:2018-03-22 出版日期:2018-06-28 发布日期:2018-06-28
  • 通讯作者: 廖健,博士,副教授/副主任医师,硕士生导师,贵州医科大学口腔医学院修复学教研室/附属口腔医院口腔修复种植科,贵州省贵阳市 550004
  • 作者简介:黄晓林,女,1992年生,汉族,贵州医科大学在读硕士,主要从事口腔修复与种植学研究。
  • 基金资助:

    国家自然科学基金(8166040135);贵州省科学技术基金([2016]1124)

Zoledronic acid promotes dental implant osseointegration in osteoporosis

Huang Xiao-lin, Yao Chao, Cheng Yu-ting, Li Fang, Wang Yong, Liao Jian   

  1. School/Hospital of Stomatology of Guizhou Medical University, Guiyang 550004, Guizhou Province, China
  • Received:2018-03-22 Online:2018-06-28 Published:2018-06-28
  • Contact: Liao Jian, M.D., Associate professor, Associate chief physician, Master’s supervisor, School/Hospital of Stomatology of Guizhou Medical University, Guiyang 550004, Guizhou Province, China
  • About author:Huang Xiao-lin, Master candidate, School/Hospital of Stomatology of Guizhou Medical University, Guiyang 550004, Guizhou Province, China
  • Supported by:

    the National Natural Science Foundation of China, No. 8166040135; the Science and Technology Foundation of Guizhou Province, No. [2016]1124

摘要:

文章快速阅读:

 

文题释义:
种植体骨结合:是指正常的改建骨和种植体直接接触,无光镜下可见到的软组织长入,并能使种植体的负荷持续传导并分散在骨组织中;骨结合包括获得骨结合的速度和长期稳定,是牙种植中种植体与骨组织之间界面的最佳结合方式,也是牙种植学研究的核心问题之一。
种植体表面处理:是指通过用机械或化学方法对种植体表面进行处理,使其形成特征性的种植体微观表面形态,改善种植体表面性能,增加种植体-骨接触面积和加快新骨沉积速度。种植体涂层就是种植体表面处理方法之一,是在钛及钛合金表面附着生物活性或生物惰性材料,使种植体表面粗糙化。
 
 
背景:唑来膦酸能有效促进口腔种植体周围骨结合形成,但其也可能会影响种植体周围软组织及血供状况,进而导致双膦酸盐相关性颌骨坏死,这也是种植修复中高度重视的一个问题。
目的:综述唑来膦酸在骨质疏松状态下口腔种植领域中应用的研究进展。
方法:由第一作者应用计算机以“bisphosphonate,zoledronic acid,implant,osseointegration”为英文检索词,以“双膦酸盐,唑来膦酸,种植体,骨结合”为中文检索词,检索PubMed、CNKI数据库中发表的相关文献,从唑来膦酸影响种植体骨结合的机制及其在体内外研究中的应用两个方面进行总结。

结果与结论:无论是全身或局部应用、单独或联合应用唑来膦酸,均可抑制骨吸收,促进新骨形成。唑来膦酸对成骨细胞和破骨细胞均有影响,可通过抑制骨吸收、促进成骨能力来发挥潜在作用,但其抑制破骨细胞的作用特点与剂量、作用时间相关,不同浓度、不同作用时间的唑来膦酸在细胞水平的具体作用机制还有待进一步深入探究。还应通过更多临床研究进一步阐明导致颌骨坏死的风险因素和决定性路径,寻找更多降低颌骨坏死风险的方法,最大优化唑来膦酸在口腔种植方面的积极作用。

ORCID: 0000-0003-4346-2902(黄晓林)

关键词: 唑来膦酸, 口腔种植, 骨结合, 骨吸收, 破骨细胞, 成骨细胞, 生物材料

Abstract:

BACKGROUND: Zoledronic acid can effectively enhance dental implant osseointegration, but it can also impair soft tissue and blood supply around the implant, eventually leading to bisphosphonate-associated osteonecrosis of the jaw. Therefore, it is a problem highly valued in implant restorations.

OBJECTIVE: To review the application of zoledronic acid in the dental implantation after osteoporosis.
METHODS: The first author searched PubMed and CNKI using computer for relevant articles concerning the potential mechanism by which zoledronic acid promotes dental implant osseointegration as well as its application in vitro and in vivo. The key words were “bisphosphonate, zoledronic acid, implant, osseointegration” in English and Chinese, respectively.

RESULTS AND CONCLUSION: Zoledronic acid has been demonstrated to inhibit bone resorption and promote bone formation via local or systemic use, single or combined use with other drugs. However, the inhibition of osteoclasts by zoledronic acid is associated with the dose and action time of zoledronic acid. Thus, further investigation on the specific mechanisms of zoledronic acid at different dose and with different action time are warranted. We should further elucidate the risk factors and determinants of osteonecrosis of the jaw through clinical studies, and then find effective approaches to reduce the risk of jaw osteonecrosis and to maximize the positive effect of zoledronic acid in the dental implantation.

Key words: Synostosis, Osteoclasts, Osteoblasts, Tissue Engineering

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