中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (5): 903-906.doi: 10.3969/j.issn.1673-8225.2012.05.033

• 器官移植学术探讨 academic discussion of organ transplantation • 上一篇    下一篇

肝移植组织中调节性T淋巴细胞的表达及分布

农村立,龙腾河,郭  堑   

  1. 广西医科大学第四附属医院(广西柳州市工人医院),广西壮族自治区柳州市  545005
  • 收稿日期:2011-09-03 修回日期:2011-12-05 出版日期:2012-01-29
  • 通讯作者: 郭堑,主任医师,广西医科大学第四附属医院(广西柳州市工人医院),广西壮族自治区柳州市 545005 prof.guoqian@yahoo.com.cn
  • 作者简介:农村立,男,1976年生,广西壮族自治区象州县人,2000年中山医科大学毕业,主治医师,主要从事肝病研究。 non.cunlli@yahoo.com.cn

Expression and distribution of regulatory T lymphocytes in liver transplant tissues

Nong Cun-li, Long Teng-he, Guo Qian   

  1. Fourth Affiliated Hospital of Guangxi Medical University (Liuzhou Worker’s Hospital), Liuzhou  545005, Guangxi Zhuang Autonomous Region, China
  • Received:2011-09-03 Revised:2011-12-05 Online:2012-01-29
  • Contact: Guo Qian, Chief physician, Fourth Affiliated Hospital of Guangxi Medical University (Liuzhou Worker’s Hospital), Liuzhou 545005, Guangxi Zhuang Autonomous Region, China prof.guoqian@yahoo.com.cn
  • About author:Nong Cun-li, Attending physician, Fourth Affiliated Hospital of Guangxi Medical University (Liuzhou Worker’s Hospital), Liuzhou 545005, Guangxi Zhuang Autonomous Region, China non.cunlli@yahoo.com.cn

摘要:

背景:调节性T细胞在动物肝脏移植免疫耐受诱导中起重要作用。
目的:探讨调节性T细胞在肝移植组织中的表达与分布。
方法:由第一作者检索Medline数据库1990-01/2010-12,万方医学网1990-01/2010-12,中国医院知识仓库1998-01/2010-12文献。英文检索词为“liver transplantation,rejection,immune tolerance,regulatory T cells”;中文检索词为“肝移植,排斥反应,免疫耐受,调节性T淋巴细胞”。
结果与结论:调节性T淋巴细胞是调节机体免疫应答的一类重要调节性细胞,具有辅助体液和细胞免疫的功能,调节性T淋巴细胞及其细胞因子在肝移植免疫中起十分重要的作用:Th1/rh2的平衡与肝移植后免疫反应密切相关,Th1细胞因子分泌增加可致肝移植排斥反应,当Th1/rh2向Th2偏移,易发生免疫耐受反应。临床评价肝移植患者免疫状态需要联合ImmuKnow、T淋巴细胞、血药浓度、肝功能指标检测等相关检查,来有效指导肝移植受体免疫抑制剂的个体化使用。
关键词:调节性T淋巴细胞;免疫耐受;肝移植;排斥反应;综述文献
doi:10.3969/j.issn.1673-8225.2012.05.033

关键词: 调节性T淋巴细胞, 免疫耐受, 肝移植, 排斥反应, 综述文献

Abstract:

BACKGROUND: Regulatory T cells play an important role in the immune tolerance induction of liver transplantation in animals.
OBJECTIVE: To explore the expression and distribution of regulatory T cells in the liver transplantation tissues.
METHODS: An online search of Medline (1990-01/2010-12), Wanfang Med Online (1990-01/2010-12) and China Hospital Knowledge Database (1998-01/2010-12) was performed for the related articles with the key words of “liver transplantation, rejection immune tolerance, regulatory T cells” in English and in Chinese.
RESULTS AND CONCLUSION: Regulatory T lymphocytes are one of the major regulatory cells in the regulation of the immune response; they assist the humoral and cell-mediated immunity. Regulatory T lymphocytes and their cytokines play a very import role in the immunoreactions of liver transplantation: the balance of Th1/rh2 is closely related with the immunoreactions after liver transplantation; the increased secretion of Th1 cytokine causes liver transplant rejection. Immune tolerance reactions are more likely to occur when the Th1/rh2 balance shifts to Th2. Clinical evaluation of the immune status in liver transplantation patients should be combined with ImmuKnow, T lymphocytes, plasma concentration, liver function testing and other related inspection, therefore the individual use of immunosuppressive agents in liver transplant recipients can be effectively guided

中图分类号: