中国组织工程研究 ›› 2012, Vol. 16 ›› Issue (5): 919-922.doi: 10.3969/j.issn.1673-8225.2012.05.037

• 器官移植学术探讨 academic discussion of organ transplantation • 上一篇    下一篇

可溶性N-乙基马来酰亚胺敏感因子结合蛋白受体与巨噬细胞的免疫学功能☆

王睿恒1,万  瑛2   

  1. 1解放军第三军医大学附属西南医院整形美容外科,重庆市400038;2解放军第三军医大学生物医学分析测试中心,重庆市 400038
  • 收稿日期:2011-11-15 修回日期:2011-12-15 出版日期:2012-01-29
  • 通讯作者: 万瑛,博士,教授,解放军第三军医大学生物医学分析测试中心,重庆市 400038 ying.wan1972@gmail.com
  • 作者简介:王睿恒☆,男,1986年生,北京市人,汉族,博士,主要从事生物材料与免疫学领域的研究。ruiheng.wang1986@gmail.com

Effect of soluble N-ethylmaleimide-sensitive factor attachment protein receptor on the immunological function of macrophages

Wang Rui-heng1, Wan Ying2   

  1. 1Plastic and Reconstructive Surgery, Southwest Hospital, the Third Military Medical University of Chinese PLA, Chongqing  400038, China; 2Testing Center of Biomedical Analysis, the Third Military Medical University of Chinese PLA, Chongqing  400038, China
  • Received:2011-11-15 Revised:2011-12-15 Online:2012-01-29
  • Contact: Wan Ying, Doctor, Professor, Testing Center of Biomedical Analysis, the Third Military Medical University of Chinese PLA, Chongqing 400038, China ying.wan1972@gmail.com
  • About author:Wang Rui-heng☆, Doctor, Plastic and Reconstructive Surgery, Southwest Hospital, the Third Military Medical University of Chinese PLA, Chongqing 400038, China ruiheng.wang1986@gmail.com

摘要:

背景:巨噬细胞进行抗原吞噬、分泌细胞因子以及迁移,均需囊泡转运,而可溶性N-乙基马来酰亚胺敏感因子结合蛋白受体家族在囊泡转运过程中发挥重要作用。
目的:全面了解可溶性N-乙基马来酰亚胺敏感因子结合蛋白受体在巨噬细胞免疫活动中的功能和作用机制。
方法:以“snare proteins,macrophages,SNARE蛋白,巨噬细胞”为检索词检索PubMed、Embase和维普数据库(2011-11),语言限定为英文或中文。经阅读题目和摘要进行初筛,排除研究方向与本文无关、内容重复性研究。另补充必要的对理解其作用机制有帮助的文献。
结果与结论:最终纳入27篇文献。可溶性N-乙基马来酰亚胺敏感因子结合蛋白受体家族是保证囊泡物质定向运输和准确卸载的分子基础,在巨噬细胞抗原吞噬、细胞因子分泌、以及移行过程中发挥作用。以可溶性N-乙基马来酰亚胺敏感因子结合蛋白受体家族为切入点对巨噬细胞免疫活动进行研究是一种合理的策略。

关键词: 可溶性N-乙基马来酰亚胺敏感因子结合蛋白受体, 巨噬细胞, 抗原吞噬, 细胞因子分泌, 细胞移行, 炎症反应

Abstract:

BACKGROUND: Macrophage performs the antigen phagocytosis, secretion of cytokines and migration through vesicle transport. Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) is a family of proteins which mediate the transportation of vesicles.
OBJECTIVE: To thoroughly understand the effects of SNARE proteins on the immune activities of macrophage and the function.
METHODS: An online search of PubMed, Embase and VIP databases (2011-11) was performed using key words of “SNARE proteins, macrophages” for articles published in English or Chinese. The irrelevant or repetitive papers were eliminated by screening for the titles and abstracts. Some essential articles that were helpful for understanding its mechanism were supplemented.
RESULTS AND CONCLUSION: A total of 27 articles were included. SNARE family is the molecular basis to ensure the direct transportation of vesicles and accurate unloading, and plays a role in antigen phagocytosis of macrophages, cytokine secretion and migration. It is a reasonable strategy for research the immune activity of macrophages with the starting point of SNARE family.  

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