中国组织工程研究 ›› 2015, Vol. 19 ›› Issue (8): 1206-1210.doi: 10.3969/j.issn.2095-4344.2015.08.011

• 组织工程骨及软骨材料 tissue-engineered bone and cartilage materials • 上一篇    下一篇

同种异体骨移植与自体骨移植修复四肢粉碎性骨折:骨性愈合及骨活性比较

杜 辉,付 勤   

  1. 中国医科大学附属盛京医院,辽宁省沈阳市 110004
  • 修回日期:2015-01-11 出版日期:2015-02-19
  • 作者简介:杜辉,男,1975年生,辽宁省台安县人,硕士,副主任医师,主要从事脊柱关节,骨外科研究。

Allogenic bone transplantation versus autologous bone grafting for repair of limb comminuted fractures: bony union and bone activity  

Du Hui, Fu Qin   

  1. Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, Liaoning Province, China
  • Revised:2015-01-11 Online:2015-02-19
  • About author:Du Hui, Master, Associate chief physician, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, Liaoning Province, China

摘要:

背景:骨移植是一种治疗四肢粉碎性骨折常用的方法,并且可以选择同种异体骨移植或者自体骨移植,两种骨移植方法各有优缺点。

目的:对比同种异体骨移植与自体骨移植修复四肢粉碎性骨折在骨性愈合及骨活性方面的临床效果。
方法:回顾性分析49例四肢粉碎性骨折患者的临床资料,按照骨移植方法分为观察组与对照组,观察组采用同种异体骨移植修复,对照组采用自体骨移植修复。观察两组骨折临床愈合时间、骨性愈合时间及骨特异性碱性磷酸酶活性,并进行比较。
结果与结论:观察组骨折愈合时间及骨性愈合时间分别为(5.8±1.2)周、(5.8±1.5)个月,对照组骨折愈合时间及骨性愈合时间分别为(6.1±1.3)周、(6.1±0.8)个月,两组间骨折愈合时间及骨性愈合时间比较差异无显著性意义(P > 0.05);观察组与对照组骨特异性碱性磷酸酶活性分别为(10.45±1.53),(13.58±1.69) μg/L,两组间比较差异有显著性意义(P < 0.05)。表明同种异体骨移植与自体骨移植修复四肢粉碎性骨折均可获得良好的临床疗效,但自体骨移植在促进骨骼愈合能力方面有一定的优势。
 

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程


全文链接:

关键词: 生物材料, 骨生物材料, 四肢骨折, 粉碎性骨折, 同种异体骨移植, 自体骨移植

Abstract:

BACKGROUND: Bone grafting is a commonly used method for treatment of limb comminuted fractures, including allogenic bone transplantation and autologous bone grafting, both of which have their own merit and demerit.

OBJECTIVE: To explore the clinical effect of bone allograft and autograft in repairing limb comminuted fractures from the aspects of bone healing and bone activity.
METHODS: A retrospective analysis was performed on the clinical data of 49 cases of limb fractures which were divided into control group (allogenic bone transplantation) and observation group (autologous bone grafting) according to treatment methods. Clinical healing time, bony union time, and bone specific alkaline phosphatase activity were observed and compared between the two groups.
RESULTS AND CONCLUSION: The bone healing time and bony union time were (5.8±1.2) weeks and (5.8±1.5) months, respectively, in the observation group and (6.1±1.3) weeks and (6.1±0.8) months, respectively, in the control group, but there was no significant difference between the two groups (P > 0.05). The bone specific alkaline phosphatase activities were (10.45±1.53) μg/L in the observation group and (13.58±1.69) μg/L in the control group, and there was a marked difference between the two groups (P < 0.05). These findings indicate that both of allogenic bone transplantation and autologous bone grafting can achieve good results in the repair of limb comminuted fractures, but the autologous bone grafting has certain advantages in the promotion of bone healing ability.  

中国组织工程研究杂志出版内容重点:生物材料;骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性;组织工程


全文链接:

Key words: Bone Transplantation, Fracture Healing, Fractures, Comminuted, Alkaline Phosphatase

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