1Central Laboratory, East Hospital, Tongji University, Shanghai   200120, China

2Department of Emergency, Shanghai Gongli Hospital, Shanghai   200135, China

3Department of Emergency, East Hospital, Tongji University, Shanghai  200120,China

Huiming Mao, Associate senior pharmacist, Central Laboratory, East Hospital affiliated Tongji University, Shanghai   200120, China Mao HM, Zhuang P, Chen XZ, Yu YM, Chen BG. Dynamic changes of lipid acylhydroperoxide and Vitamin E plasma levels in ischemic stroke patients. Neural Regen Res 2008;3(6):687-9

Abstract

BACKGROUND: Studies have shown that malondialdehyde is the metabolic product of lipid peroxidation. However, detection of the intermediate metabolic product of lipid peroxidation, acylhydroperoxide (AHP), has rarely been reported.

OBJECTIVE: To document concentrations of the intermediate metabolic product of lipid peroxidation, AHP, during different stages of ischemic cerebral infarction.

DESIGN, TIME AND SETTING: Forty-eight patients with cerebral infarction from the East Hospital of Tongji University, and thirty-three students of Shanghai Geriatric University (healthy controls), in a case match-control study from April 2000 to January 2001.

PARTICIPANTS: Based on different disease states, patients were separated into three groups: acute (n = 19), convalescent (n = 17), and chronic(n = 12). The healthy, control group consisted of 33 students, who were not treated with Vitamin E during the two weeks.

METHODS: AHP concentration was detected by an ultraviolet spectrophotometric method, and plasma Vitamin E levels were detected by a visual spectrophotometric method.

MAIN OUTCOME MEASURES: Plasma lipid AHP and Vitamin E levels of patients and healthy control groups.

RESULTS: Plasma lipid AHP levels of patients in the acute group significantly increased compared with healthy control and convalescent groups (F = 4.40, P < 0.01), but plasma Vitamin E levels significantly decreased compared with the healthy control group (F = 3.07, P < 0.05). In the convalescent group, plasma lipid AHP and the Vitamin E levels were not significantly different from the healthy control (P > 0.05). No significant differences were detected in plasma lipid AHP and Vitamin E levels in the chronic group compared to the control and convalescent groups (P > 0.05).

CONCLUSIONS: Lipid peroxidation, as evidenced by high plasma lipid AHP and low Vitamin E levels, occurs primarily during the acute stage of patients with cerebral infarction.

Key Words: cerebral infarction; ischemia; lipid acylhydroperoxide; Vitamin E

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