Department of Rehabilitation Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou   646000, Sichuan Province, China

Dan Yang★, Studying for master’s degree, Department of Rehabilitation Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, Sichuan Province, China Yang D, Yu Q. Correlation between synaptic plasticity, associated proteins, and rehabilitation training in a rat model of cerebral infarction. Neural Regen Res 2008;3(6): 670-3

Abstract

All motions provide sensory, motoric, and reflexive input to the central nervous system, as well as playing an important role in cerebral functional plasticity and compensation. Cerebral plasticity has become the theoretical basis of neurorehabilitation. Studies of cerebrovascular disease, in particular, demonstrate that regeneration is accompanied by multiple forms of plasticity, such as functional and structural, in different phases of stroke rehabilitation. This study was designed to measure synaptic plasticity and expression of associated proteins to analyze the effect of rehabilitation training on learning and memory in a rat model of cerebral infarction. Results suggest that rehabilitation training increases expression of nerve growth factor associated protein 43, brain-derived neurotrophic factor, and neural cell adhesion molecules, and also promotes cerebral functional plasticity.

Key Words: cerebral infarction; rehabilitation training; synaptic plasticity; associated protein; rats

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