2010.19 - CRTER NRR BRM JCS SCIR TCT TCMC TOGT

2010.19

Publisher：liyzbs Publish Time：Tuesday, November 30, 2010
Source：NRR

Research and Reports

Stem Cells and Neuroregeneration

Synaptic development in the injured spinal cord cavity following co-transplantation of fetal spinal cord cells and autologous activated Schwann cells
Neural Regeneration Research 2010;5(19): 1445
Wendong Ruan, Yuan Xue, Ninghua Li, Xiaotao Zhao, Huajian Zhao, Peng Li
Supported by: the Tianjin Science and Technology Commission Key Project, No. 07JCZDJC08000*; the Natural Science Foundation of China, No. 30772193*, 30571876*; National High-Tech R&D Program of China (863 Program), No. 2007AA04Z235*.

Research Highlights

BACKGROUND: Co-transplantation of fetal spinal cord cells and autolo

gous activated Schwann cells was used to treat spinal cord injury in adult Wistar rats. Histological and immunohistochemical techniques were used to observe the newly generated synaptic development of fetal spinal cord cells in the injured spinal cavity.

Can muscle-derived stem cells serve as seed cells to repair spinal cord injury
Neural Regeneration Research 2010;5(19): 1451
Xifan Mei, Chang Liu, Gang Lü, Yansong Wang, Quanshuang Li, Zhanpeng Guo, Shiqiong Liu, He Zhang
Supported by: the Natural Science Foundation of Liaoning Province, No. 20072204*.

Research Highlights

BACKGROUND: Using stem cell biology and tissue engineering, rat muscle-derived stem cells (MDSC) were in vitro isolated, cultured and induced to neural cells. With adenovirus as carrier, MDSCs carrying green fluorescent protein were transplanted into injured spinal cord. Behavior scoring and fluorescence microscopic observation demonstrated MDSC can repair spinal cord injury, and function as seed cells in neural tissue engineering to repair spinal cord injury.

Ultrastructure of neuronal-like cells differentiated from adult adipose- derived stromal cells
Neural Regeneration Research 2010;5(19): 1456
Changqing Ye, Xiaodong Yuan, Hui Liu, Yanan Cai, Ya Ou

Research Highlights

BACKGROUND:β-mercaptoethanol induces in vitro, adult, adipose-derived, stromal cells (ADSCs) to differentiate into neurons. Results of morphological and ultrastructural changes show that ADSCs exhibit a typical neuronal morphology after induction for 5 hours with a large number of characteristic Nissl bodies and mitochondria, demonstrating these neuronal-like cells have some similar structures of neurons.

Activin A maintains cerebral cortex neuronal survival and increases voltage-gated Na+ neuronal current
Neural Regeneration Research 2010;5(19): 1464
Jingyan Ge, Yinan Wang, Haiyan Liu, Fangfang Chen, Xueling Cui, Zhonghui Liu
Supported by: the National Natural Science Foundation of China, No. 30903123*, 30901329*; the Project of Science and Technology of Jilin Province, No. 20090741*, 20090185*

Research Highlights

BACKGROUND: Since 1990, Nature firstly reported that activin A as neuron survival molecule can maintain the survival of in vitro cultured hippocampal neurons. In 2008, Neuroscience reported that activin A can promote neuron Ca++ current. In 2006, our laboratory reported that activin A promoted the growth of chick embryo spinal cord dorsal root ganglion nervous process and inhibited NO secretion. This study firstly reported that activin A can maintain the survival of cortical neurons of mice cultured in vitro for a long time, and firstly observed promoting effects of activin A on nerve cell voltage dependence sodium current using patch clamp. The present study not only discovered new effects of activin A, but also explained the mechanism of activin A affecting neuron function by regulating VIP and iNOS expression.

Electrical stimulation upregulates angiopoietin-1/Tie-2 mRNA expression in a rat model of focal cerebral ischemia
Neural Regeneration Research 2010;5(19): 1470
Shasha Li, Yonghong Yang, Qiang Gao, Jing He, Chengqi He
Supported by: the National High-Tech R&D Program of China (863 Program), No 2007AA022Z482*

Research Highlights

BACKGROUND: The present study utilized self-made multi-channel low-frequency dysphagia treatment apparatus to treat ischemic stroke and observed neurological behavior, angiopoietin-1/tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2 expression changes in focal brain ischemic rats to investigate the protective effect of this treatment apparatus from functional improvement and angiogenesis aspects.

Techniques and Methods

Components and sequential changes in event-related potential induced by gaze orientation processing under a reflective attention cue paradigm
Neural Regeneration Research 2010;5(19): 1475
Yingdi Li, Xuemin Zhang, Yan Song, Qing Feng
Supported by: the Applied Experimental Psychology Project of Beijing Key Laboratory from 2008 to 2009, No. JD100270541*; the Scientific Research Foundation of Beijing Normal University, No. 2009SC-3*

Research Highlights

BACKGROUND: This study used gaze orientation attention cue paradigm and event-related potential and clarified the dispute and inconsistent conclusion addressing neuromechanism of attention processing by reflective attention cue and localization task, and simultaneously found that the attention processing under reflective attention condition was similar to voluntary attention neuromechanism, and found that anterior directing attention negativity and early directing attention negativity are important in reflective attention.

Functional localization of the cortical motor area in the brain: electrocorticogram analysis
Neural Regeneration Research 2010;5(19): 1480
Tao Jiang, Xiaoming Wu, Binggang Ye, Sijuan Huang

Research Highlights

BACKGROUND: ①Based on cortical electrostimulation, the new method of functional localization and conclusion in the nerve cortex were characterized by fast, exact, non-invasion to cerebral cortex, avoiding secondary surgery. ②This study introduced feature extraction and wavelet analysis of classification in the method of motor area functional localization and verified its feasibility and features.

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