2010.22 - CRTER NRR BRM JCS SCIR TCT TCMC TOGT

2010.22

Publisher：liyzbs Publish Time：Thursday, December 16, 2010
Source：NRR

Research and Reports

Neurodegenerative Diseases and Neuroregeneration

Synthetic protease inhibitor-induced inclusions in PC12 cells: potential proteomic characterization of six subunits in the 26S proteasome
Neural Regeneration Research
2010;5(22): 1685
Mingxiu Tian, Xing'an Li, Yingjiu Zhang, Yihong Hu, Ming Chang, Tao Liu, Danping Wang, Yu Zhang, Linsen Hu
Supported by:the Science and Technology Commission Foundation of Jilin Province, No. 200505200*; the Distin-guished Professor Founda-tion of Jilin University, No. 450011011204*

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Research Highlights

The present study obtained information of synthetic proteasome inhibitor-induced inclusions using proteome analysis and qualitatively analyzed the 26S proteasome non-adenosine triphosphatase subunit 11 to facilitate studies of proteasome subunit in Lewy bodies.

A Hopfield-like hippocampal CA3 neural network model for studying associative memory in Alzheimer's disease
Neural Regeneration Research
2010;5(22): 1694
Wangxiong Zhao, Qingli Qiao, Dan Wang
Supported by:the National Natural Science Foundation of China, No. 30870649*; the Natural Science Foundation of Tianjin, No. 08JCYBJC03300*

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Research Highlights

1. This study established a three-layer network model according to the simplified anatomic structure of the CA3 region. Each layer represents CA3a, CA3b and CA3c regions. 2. The model established in this study has both auto-associative memory and hetero-associative memory functions. This study analyzed effects of Alzheimer’s disease on hetero-associative memory function.

Divalent metal transporter 1 expression and iron deposition in the substantia nigra of a rat model of Parkinson's disease
Neural Regeneration Research
2010;5(22): 1701
Yangwen Song, Xin Chen, Chun Li, Nan Zhang
Supported by:the Scientific Research Common Program of Beijing Municipal Com-mission of Education, No. KM200610025008*

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Research Highlights

Results of the present study demonstrated that no obvious iron deposition was observed in the substantia nigra during early stages after damage, but significant iron deposition was detected at 8 weeks post-injury. These results demonstrate that extensive iron deposition at a period of time post-SN injury, which could be regarded as an early time window of iron deposition. Dopaminergic neurons loss appeared accompanied by increased divalent metal transporter1 expression in substantia nigra, while iron deposition was detected at 8 weeks post-injury. This primarily elucidates correlation of dopaminergic neurons loss with divalent metal transporter1 and iron deposition in substantia nigra.

Adenosine triphosphate-sensitive potassium channel opener protects PC12 cells against hypoxia-induced apoptosis through PI3K/Akt and Bcl-2 signaling pathways
Neural Regeneration Research
2010;5(22): 1706
Hong Zhang, Chunhong Jia, Danyang Zhao, Yang Lu, Runling Wang, Jia Li
Supported by:the Natural Science Foundation of Liaoning Province, No. 20052097*, 2008225010*

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Research Highlights

This study for the first time demonstrated that pinacidil, a KATP opener, further activates downstream Bcl-2 expression by activation of the phosphatidylinositol-3 kinase/Akt signaling pathway, exerting protective effects on post-ischemic PC 12 cell apoptosis.

Traditional Chinese Medicine and Neuroregeneration

Specific cerebral activation following true and sham Waiguan (SJ 5) needling: functional magnetic resonance imaging evidence
Neural Regeneration Research
2010;5(22): 1712
Yong Huang, Xinsheng Lai, Baoci Shan, Chunzhi Tang, Junjun Yang, Tongjun Zeng, Guifeng Zhang, Jiarong Chen, Yangjia Lu
Supported by:the National 973 Program of China, No. 2006CB504505*; the National Natural Science Foundation of China, No. 90709027*

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Research Highlights

This study observed the regional cerebral activation of Waiguan (SJ5) acupoint following true needling in true Waiguan (SJ5) acupoint, sham needling in true Waiguan (SJ5) acupoint and true needling in a sham point using functional magnetic resonance imaging, which has a great significance in exploring effects of acupoints on the central nervous system in combination of traditional theory.

Effects of moxibustion on heat-shock protein 70 expression in the spinal cord and colonic mucosa in a rat model of ulcerative colitis
Neural Regeneration Research
2010;5(22): 1717
Li Qi, Yin Shi, Luyi Wu, Jingping Mu, Linying Tan, Xiaopeng Ma, Huirong Liu, Shifen Xu, Huangan Wu
Supported by:the National Basic Research Program of China (973 Program), No. 2009CB522900*; the Shanghai Leading Academic Discipline Project, No. S30304*

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Research Highlights

Immunohistochemistry and real time fluorescent quantitative PCR technique were used to study the mechanism of local intestinal tract and center of spinal cord of rats with colonic mucosa injury of ulcerative colitis rats. This study introduced HSP to verify the efficacy of moxibustion in protecting the colonic mucosa and to study its action mechanism. This study provided new scientific evidence for studying the efficiency of moxibustion for treatment of ulcerative colitis in clinic and laid credible modern scientific basis for explaining action mechanism of moxibustion.

Combined effects of electroacupuncture and anti-depression drugs on the hippocampus and frontal lobe
Neural Regeneration Research
2010;5(22): 1723
Dongmei Duan, Ya Tu, Shuang Jiao, Liping Chen
Supported by:the National Natural Science Foundation of China, No. 30701122*; the Key Program of Beijing Natural Science Foundation, No. 7051003*

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Research Highlights

(1) The present study utilized MR spectroscopy to observe indexes of brain functional activities and investigate correlation with mental disorder scales of depression patients following electroacupuncture treatment. (2) The depression diagnosis and curative effect evaluation were performed using international standards, and fluoxetine was used as control. The present study attempted to observe and evaluate the clinical treatment effect of electroacupuncture on depression through systematic clinical experiments to provide theoretical evidence for extensive application of electroacupuncture in depression treatment.

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