2011.03 - CRTER NRR BRM JCS SCIR TCT TCMC TOGT

2011.03

Publisher：liyzbs Publish Time：Monday, February 21, 2011
Source：NRR

Research and Reports

Chinese Medicine and Neuroregeneration

Baicalin and jasminoidin effects on gene expression and compatibility in the hippocampus following focal cerebral ischemia
Neural Regeneration Research
2011;6(3): 165
Lin Guo, Fanyun Meng, Guodong Zhang, Jing Zhao, Zhanjun Zhang, Caixiu Zhou, Zhong Wang
Supported by:the Postdoctoral Science Foundation of China, No. 20090450553*

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Research Highlights

(1) Based on the current primary analysis of pathway networks, the present study analyzed the mechanisms underlying network regulation of single ingredients and compatibility, investigated the correlation between genomes and proteomes from local to whole, and distinguished the overall mechanisms of prescription compatibility using ingenuity pathway analysis software. (2) Using ingenuity pathway analysis software, the present study analyzed single ingredient intervention of pathophysiological processes of neuroprotection in mice with cerebral ischemia, as well as a full-scale analysis on functional pathway networks to better understand the complex system of prescriptions and the relationship between “gene-disease-prescription.”

Senegenin promotes in vitro proliferation of human neural progenitor cells
Neural Regeneration Research
2011;6(3): 171
Fang Shi, Zhigang Liang, Zixuan Guo, Ran Li, Fen Yu, Zhanjun Zhang, Xuan Wang, Xiaomin Wang
Supported by:the National Basic Research Program of China-973 Project, No. 2006CB500700*; the National Natural Science Foundation of China, No. 30500255*; the Natural Science Foundation of Beijing, No. 5102010*

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Research Highlights

(1) The present study first confirmed that senegenin contributed to in vitro proliferation of human mesencephalon-derived neural progenitor cells. (2) This study explored and discovered the possible signal transduction mechanism of senegenin in the mitogen-activated protein kinase signal transduction pathway.

Xuefuzhuyu injection induces neuronal differentiation of rat bone morrow mesenchymal stem cells
Neural Regeneration Research
2011;6(3): 177
Yanqing Yin, Bing Chen, Junlong Ke, Wei Mo, Xinhui Zou, Yuansheng Liang
Supported by:the Youth Science Foundation of Affiliated Hospital of Guangdong Medical College, No. 2009k08*

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Research Highlights

Chinese compound medicine Xuefuzhuyu injection served as an inducer for the first time, rat bone marrow mesenchymal stem cells can be induced to differentiate into neuron-like cells in vitro, and the optimal concentration is confirmed 3 g/L.

Protective effects of berberine against amyloid beta-induced toxicity in cultured rat cortical neurons
Neural Regeneration Research
2011;6(3): 183
Jing Wang, Yanjun Zhang, Shuai Du, Mixia Zhang
Supported by:the Key Project of Ministry of Education of China, No. 208009*; the National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China, No. 2009ZX09308-005*

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Research Highlights

The present study analyzed the potential protective effect of berberine against amyloid β-induced cytotoxicity in cerebral cortical neurons, and investigated its correlation with the reduction of neuronal apoptosis and the inhibition of abnormally activated caspase-3 protein expression.

Neuroprotective effects of salvianolic acid B on secondary spinal cord damage
Neural Regeneration Research
2011;6(3): 188
Zhizhong Ye, Yubin Deng, Hongfu Wu, Danhui Gan
Supported by:the National Natural Science Foundation of China, No. 30901547*; a Grant from Guangdong Province Technological Plan, No. 2009B050200010*; a Grant from Chinese Medicine Bureau of Guangdong Province, No. 2008078*; Grants from Science and Technology Plan Project of Dongguan City of Guangdong Province, No. 200910815255*, 2007108101007*

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Research Highlights

(1) Salvianolic acid B relieved damage to spinal cord cells, promoted recovery of motor function disturbance, and reduced the effects of spinal cord injury in rats with acute spinal cord injury. (2) The anti-inflammatory effects of Salvianolic acid B combined with tumor necrosis factor-α antagonist etanercept were most significant following secondary damage to the spinal cord.

Curcumin reduces inflammatory reactions following transient cerebral ischemia/reperfusion injury
Neural Regeneration Research
2011;6(3): 219
Jing Zhao, Shanshan Yu, Lan Li, Xuemei Lin, Yong Zhao
Supported by:the National Natural Science Foundation of China, No. 30900457*

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Research Highlights

① The present study investigated anti-inflammatory characteristics of curcumin, as well as the protective effects and action mechanisms of curcumin, on ischemic cerebrovascular disease injury. ② Results showed that curcumin significantly inhibited inflammatory reactions following ischemia/reperfusion injury in rats by regulating inflammation-related proteins and cytokines, such as tumor necrosis factor-α, interleukin-1β, and nuclear factor kappa B.

Chinese Medicine and Neuroregeneration

Clinical effects of acupuncture therapy for vascular dementia
Neural Regeneration Research
2011;6(3): 193
Lei Zhao, Yi Guo, Jun Xiong, Wei Wang, Yuanhao Du, Lijuan Yan
Supported by:the National Natural Science Foundation of China, No. 30772838*; the Education Funded Projects of High-Tech Japanese Ministry, No. 343 50537030*; the Scientific and Technological Support Issue of National “Eleventh Five-Year” Plan Period, No. 2006BAI12B01*

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Research Highlights

▲ A highly selective radicotomy model was established to compare trophic actions of motor and sensory nerves on skeletal muscle. ▲ A preferential reconstruction of motor nerves in the early stage of nerve injury could reduce skeletal muscle cell apoptosis, as well as attenuate or reverse skeletal muscle atrophy.

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