2011.13
Publisher：mengjjzbs Publish Time：Saturday, June 11, 2011
Source：NRR |
| Research and Reports |
| Stem Cells and Neuroregeneration |
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Prolonged propagation of rat neural stem cells relies on inhibiting autocrine/paracrine bone morphogenetic protein and platelet derived growth factor signals*****☆
Neural Regeneration Research
2011;6(13): 965-971
Yirui Sun1, 2, Liangfu Zhou1, Xing Wu1, Hua Liu2, Qiang Yuan2, Ying Mao1, Jin Hu1
Supported by: the National Natural Science Foundation of China, No. 81000518*; China Postdoctoral Science Foundation, No. 201003237*; the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry of China*; Shanghai Pujiang Program by Science and Technology Commission of Shanghai Municipality, No. 09PJ1408300*; Key Basic Research Project by Science and Technology Commission of Shanghai Municipality, No. 10JC1402300* |
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Using monolayer cultures of rat cells, we observed autocrine/paracrine bone morphogenetic protein and platelet derived growth factor signals. The results revealed that antagonizing both signals led to the long-term propagation of stable rat neural stem cell lines. | | |
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Brain-derived neurotrophic factor induces neuron-like cellular differentiation of mesenchymal stem cells derived from human umbilical cord blood cells in vitro*☆
Neural Regeneration Research
2011;6(13): 972-977
Lei Chen1, Zhongguo Zhang2, Bing Chen3, Xiaozhi Liu1, Zhenlin Liu1, Hongliang Liu1, Gang Li1, Zhiguo Su1, Junfei Wang1, Guozhen Hui4
Supported by: the National Basic Research Program of China (973 Program), No. 2005CB522604* |
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Brain-derived neurotrophic factor can induce human umbilical cord blood-derived mesenchymal stem cells to differentiate into neuron-like cells in vitro. | | |
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Bone marrow mesenchymal stem cell transplantation for treatment of spinal cord injury An in vivo magnetic resonance imaging tracking study***☆
Neural Regeneration Research
2011;6(13): 978-982
Yu Liu1, Boai Zhang1, Yi Song2, Yubin Deng3, Yanjie Jia1, Qiyong Gong4
Supported by: the National Basic Research Program of China (973 Program), No. 2005CB522604* |
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This study used bone marrow mesenchymal stem cells (BMSCs) for the treatment of spinal cord injury in rats via the subarachnoid cavity. The study observed the migration and distribution of green fluorescent protein- and superparamagnetic iron oxide-labeled BMSCs in vivo, and verified the feasibility of magnetic resonance imaging tracking in vivo. | | |
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Bilateral olfactory ensheathing cell transplantation promotes neurological function in a rat model of cerebral infarction****
Neural Regeneration Research
2011;6(13): 983-987
Zhihua Yang1, Wenli Sheng2, Huiyong Shen3, Qinghua Hou2, Rui Li2, Jinsheng Zeng2, Ruxun Huang2
Supported by: the National Natural Science Foundation of China, No. 39700048*, 30271378*; a grant from Education Bureau of Guangzhou, No. 61092*; a grant from Science and Technology Department of Guangdong Province, No. 2009B030801354* |
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In this study, olfactory ensheathing cells (OECs) were transplanted into the cortices of infarcted, normal, and bilateral hemispheres. Results showed that the OECs transplanted into the normal hemisphere promoted neurological function. The transplanted OECs migrated to the infarct focus and promoted nerve cell regeneration surrounding the infarct focus. Moreover, bilateral cortical transplantation exhibited superior effects over unilateral transplantation. | | |
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Construction of a three-dimensional bionic nerve conduit containing two neurotrophic factors with separate delivery systems for the repair of sciatic nerve defects*☆
Neural Regeneration Research
2011;6(13): 988-994
Zhiyue Li1, Qun Zhao1, Ran Bi1, Yong Zhuang1, Siyin Feng2
Supported by: the National Natural Science Foundation of Hunan Province, No. 06JJ4022* |
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|Abstract|HTML|PDF|Supplementary |Editor’s Choice
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The present study constructed a three-dimensional bionic nerve conduit containing two neurotrophic factors with separate delivery systems. The conduit contains many curved microtubules in lumens, which greatly mimic the coursing of nerve bundles. Therefore, the three-dimensional bionic nerve conduit shows better effects in repair of sciatic nerve defects than autologous nerve and previously developed fistular poly(lactic-co-glycolic acid) nerve conduits. | | |
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