2011.21 - CRTER NRR BRM JCS SCIR TCT TCMC TOGT

2011.21

Publisher：yinlzxb Publish Time：Wednesday, August 24, 2011
Source：NRR

Research and Reports

Traditional Chinese Medicine and Neuroregeneration

Therapeutic window of Qingkailing injection for focal cerebral ischemia/reperfusion injury★
Neural Regeneration Research 2011;6(1605-1611):
Fafeng Cheng1, Wenting Song2, Xianggen Zhong1, Yi Lu1, Shaoying Guo1, Dong Wang1, Weipeng Zhao1, Qingguo Wang1
Supported by: the Science and Technology Major Projects for Major New Drugs, No. 2009ZX09102-136*

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Research Highlights

Qingkailing injection reduced reactive oxygen species production, decreased malondialdehyde content, increased superoxide dismutase activity, and declined NADPH oxidase activity. The therapeutic window of Qingkailing injection can extend to 9 hours for cerebral ischemia/reperfusion in mice.

Identification of differentially expressed proteins in SH-SY5Y cells treated with resveratrol★
Neural Regeneration Research 2011;6(1612-1617):
Ying Wang1, Zhong Dong1, Hongyan Fan2, Ming Chang1, Guoyi Li1, Linsen Hu1

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Research Highlights

2-dimensional difference gel electrophoresis in combination with matrix-assisted laser desorption ionization time-of-flight mass spectrometry identified four differentially expressed proteins in SH-SY5Y cells treated with resveratrol: endoplasmic reticulum oxidoreductin 1-like protein alpha, p21-activated kinase 1, ARCN1, and T cell receptor beta chain.

Geniposide protects human neuroblastoma SH-SY5Y cells against corticosterone-induced injury★
Neural Regeneration Research 2011;6(1618-1622):
Liping Chen1, Fawei Wang1, Miao Geng2, Hongyan Chen2, Dongmei Duan1
Supported by: the Capital Specific Clinical Medical Subject of Beijing Science and Technology Commission, No. Z090507017709030*

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Research Highlights

This is the first study to show that geniposide protects SH-SY5Y cells from high-dose corticosterone-induced injury. Geniposide improves SH-SY5Y cell survival, increases the number of cells in the G2 phase of the cell cycle, reduces P21 and P53 protein expression, and inhibits apoptosis.

Triptolide protects astrocytes from hypoxia/ reoxygenation injury★
Neural Regeneration Research 2011;6(1623-1627):
Minfang Guo1, Hongcui Fan1, Jiezhong Yu1, Ning Ji1, Yongsheng Sun1, Liyun Liang1, Baoguo Xiao1, 2, Cungen Ma1
Supported by: the National Natural Science Foundation of China, No. 81070957*; the Natural Science Foundation of Shanxi Province, No. 2008011082-1*

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Research Highlights

Triptolide treatment could protect astrocytes against hypoxia/reoxygenation injury through the inhibition of inflammatory factors such as interleukin-1β, tumor necrosis factor α and interleukin-6, as well as matrix metalloproteinase-9.

Effect of Yiqi Bushen prescription on hippocampal neuronal apoptosis in diabetic rats★
Neural Regeneration Research 2011;6(1628-1634):
Deshan Liu, Weiwei Lin, Wei Gao, Ping Chang, Wei Li
Supported by:the Science and Technology Development Program of Shandong Province, No. 032050116*; the Natural Science Foundation of Shandong Province, No. ZR2010HM077*; the 20 Staff Foundation of 1020 Project of Shandong Province*

|Abstract|HTML|

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Research Highlights

Hyperglycemia and/or hypoxia in hippocampal tissues have been shown to contribute to cognitive dysfunction in diabetes mellitus. In vivo and in vitro experiments demonstrated that Yiqi Bushen prescription can improve the hypoxic microenvironment and inhibit hippocampal neuronal apoptosis by decreasing hypoxia-inducible factor-1α expression and increasing Bcl-2 expression, thereby improving cognitive impairment in diabetic rats.

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