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2011.27

Publisher:yinlzxb  Publish Time:Saturday, October 29, 2011 
Source:NRR

    Research and Reports
     Traditional Chinese Medicine and Neuroregeneration

1

Effects of Scutellaria baicalensis on neurogenesis in the hippocampal dentate gyrus and on spatial memory of adult rats★
Neural Regeneration Research 2011;6(2085-2093):
Sun-Hwa Lee1, Byung-soo Ahn1, Bong-soo Lim1, Seong-Kyu Kim1, Sam-Ki Kim1, Dae-Il Lee1, Sung-Rae Cho2, Deok-Gon Kim3, Jae-Bok Han1, Byung-Il Min1, 4

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  Research Highlights
BACKGROUND:Administration of Scutellaria baicalensis increased cell proliferation, including a subset of astrocytes, and differentiation of cells into mature neurons in the hippocampal dentate gyrus of adult rats. In addition, Scutellaria baicalensis improved spatial memory and learning.

2

Protection of 3’-methoxy-puerarin against focal brain ischemia and its association with c-fos expression★
Neural Regeneration Research 2011;6(2094-2099):
Sha Liu1, Yibing Zhang1, Guiyou Du2, Yong Zhao2, Haifeng Cui2, Chunyu Cao2

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BACKGROUND:Results demonstrated that 3’-methoxy-puerarin can protect brain tissues from focal ischemia, reduce pe-roxidation damage, and downregulate c-fos gene expression.

3

Flavonoids from the stems and leaves of Scutellaria baicalensis Georgi attenuate H2O2-induced oxidative damage to rat cortical neurons★
Neural Regeneration Research 2011;6(2100-2104):
Yongping Liu, Kai Cao, Hong Miao, Jianjun Cheng, Yazhen Shang
Supported by:the State Administration of Traditional Chinese Medicine, People’s Republic of China, No. 02-03-ZP18*; Hebei Provincial Education Department, No. 20015*; Hebei Provincial Hundred Outstanding Innovated Talents, First Batch*

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BACKGROUND:The stems and leaves of Scutellaria baicalensis Georgi are the source of a flavonoid extract, called SSF. In this study, SSF, at a concentration range of 18.98–75.92 μg/mL, protected primary cortical cell cultures against H2O2 toxicity by inhibiting malondialdehyde formation and by suppressing reductions in superoxide dismutase, glutathione peroxidase and Na+-K+-ATPase activities.

4

Bilobalide inhibits the expression of aquaporin 1, 4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia★
Neural Regeneration Research 2011;6(2105-2111):
Haiming Qin1, 2, Fulin Song2, Hongguang Han2, Hong Qu2, Xingwen Zhai1, Bin Qin1, Song You1
Supported by:a Research Subject of General Hospital of Shenyang Military Area Command of Chinese PLA*

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BACKGROUND:Pretreatment with bilobalide can inhibit aquaporin 1, 4 expression in edema brain tissue, alleviate brain edema, simultaneously inhibit glial fibrillary acidic protein expression, and lighten reactive gliosis in an adult rat model of permanent middle cerebral artery occlusion.

5

(-)-Epigallocatechin-3-gallate protects spiral ganglion neurons against amikacin-induced apoptosis★
Neural Regeneration Research 2011;6(2112-2117):
Qianghe Liu1, Dinghua Xie2, Xinming Yang2

  |Abstract|HTML|PDF|Supplementary |Editor’s Choice
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  Research Highlights
BACKGROUND:(-)-epigallocatechin-(3)-gallate can effectively inhibit amikacin-induced spiral ganglion neuron apoptosis by inhibiting Bax, caspase-3 and caspase-6 expression and increasing Bcl-2 expression.


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